220631-07-2Relevant academic research and scientific papers
Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA
Yang, Su Hui,Van, Hue Thi My,Le, Thanh Nguyen,Khadka, Daulat Bikram,Cho, Suk Hee,Lee, Kyung-Tae,Lee, Eung-Seok,Lee, Young Bok,Ahn, Chang-Ho,Cho, Won-Jea
scheme or table, p. 5493 - 5497 (2010/12/19)
Various substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model. Most of the synthesized compounds showed excellent potency in eight different human tumor cell lines as expected. In order to fin
Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives
Cho, Won-Jea,Kim, Eui-Ki,Park, Myun-Ji,Choi, Sang-Un,Lee, Chong-Ock,Cheon, Seung Hoon,Choi, Bo-Gil,Chung, Byung-Ho
, p. 2449 - 2458 (2007/10/03)
In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA. Copyright (C) 1998 Elsevier Science Ltd.
Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents
Cho, Won-Jea,Park, Myun-Ji,Chung, Byung-Ho,Lee, Chong-Ok
, p. 41 - 46 (2007/10/03)
To investigate the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinolin-1(2H) -one 2, diverse substituted 3-arylisoquinolines were synthesized and tested in vitro antitumor activity against five human tumor cell lines. The results showed a broad antitumor spectrum for a series of 3-arylisoquinolines.
