220631-15-2

Upstream product

• 203628-40-4 3-dimethylamino-2-methyl-N,N-dimethylbenzamide 
• 874-90-8 4-methoxybenzonitrile 
• 203628-19-7 5-(dimethylamino)-3-(4-methoxyphenyl)isoquinolin-1(2H)-one 

Relevant academic research and scientific papers

Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives

In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA. Copyright (C) 1998 Elsevier Science Ltd.

Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents

To investigate the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinolin-1(2H) -one 2, diverse substituted 3-arylisoquinolines were synthesized and tested in vitro antitumor activity against five human tumor cell lines. The results showed a broad antitumor spectrum for a series of 3-arylisoquinolines.