220644-02-0 Usage
Uses
Used in Research Applications:
Z-Val-Ala-DL-Asp-fluoromethylketone is utilized as a research tool for studying the role of caspases in apoptosis. Its ability to inhibit caspase activity allows scientists to investigate the mechanisms of programmed cell death and the pathways involved in various biological processes and diseases.
Used in Pharmaceutical Development:
In the pharmaceutical industry, Z-Val-Ala-DL-Asp-fluoromethylketone is considered for development as a potential therapeutic agent. Its caspase-inhibitory properties make it a candidate for treating diseases where dysregulation of cell death pathways contributes to pathology, such as neurodegenerative disorders, ischemic injuries, and certain inflammatory conditions.
Used in Drug Discovery:
Z-Val-Ala-DL-Asp-fluoromethylketone serves as a lead compound in drug discovery efforts aimed at identifying new molecules with improved potency, selectivity, and pharmacokinetic properties for modulating caspase activity. This can lead to the development of more effective treatments with fewer side effects for conditions associated with aberrant apoptosis.
Used in Diagnostic Tools:
Z-Val-Ala-DL-Asp-fluoromethylketone may also be employed in the development of diagnostic tools to assess caspase activity levels in biological samples. This can help in the early detection of diseases and the monitoring of treatment responses in patients with conditions related to apoptosis dysregulation.
Check Digit Verification of cas no
The CAS Registry Mumber 220644-02-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,6,4 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 220644-02:
(8*2)+(7*2)+(6*0)+(5*6)+(4*4)+(3*4)+(2*0)+(1*2)=90
90 % 10 = 0
So 220644-02-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15?,18-/m0/s1
220644-02-0Relevant academic research and scientific papers
Synthesis of P1 Aspartate-Based Peptide Acyloxymethyl and Fluoromethyl Ketones as Inhibitors of Interleukin-1β-Converting Enzyme
Revesz, Laszlo,Briswalter, Chantal,Heng, Richard,Leutwiler, Albert,Mueller, Rudolf,Wuethrich, Hans-Juerg
, p. 9693 - 9696 (2007/10/02)
Improved procedures have been developed for the synthesis of P1 aspartate-based 2,6-dichlorobenzoyloxymethyl ketone 1 and fluoromethyl ketone 2, the prodrugs of two potent ICE-inhibitors. 1 was prepared from (R)-trans-4,5-O-isopropylidene-4,5-dihydroxy-2-
