220648-36-2

Upstream product

• 220259-83-6 1-carbamoylmethyl-1,2-dihydro-2-(4-toluenesulfonimido)-5-benzoylpyridine 
• 220648-33-9 2-trifluoroacetamido-3-iodo-6-benzoylimidazo<1,2-a>pyridine 
• 220648-34-0 2-trifluoroacetamido-3-methylthio-6-benzoylimidazo<1,2-a>pyridine 
• 220259-89-2 2-trifluoroacetamido-6-benzoylimidazo<1,2-a>pyridine 
• 220259-66-5 1,2-dihydro-2-toluenesulfonimido-5-benzoylpyridine 
• 220648-37-3 2-trifluoroacetamido-3-methylsulfonyl-6-benzoylimidazo<1,2-a>pyridine 

Downstream Products

• 251368-74-8 2-Amino-3-methylsulfonyl-6-(1-phenyl-2-cyanovinyl)imidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

Anti-viral compounds

The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N—OH, O, or CHR1; R1is hydrogen, halo, CN, C1-C4alkyl, —C≡CH, CO(C1-C4alkyl), CO2(C1-C4alkyl), or CONR2R3; R2and R3are independently hydrogen or C1-C4alkyl; A′ is hydrogen, halo, C1-C6alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula R4is C1-C6alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R6is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4alkyl, or CO2(C1-C4alkyl), C1-C4alkoxy; or a pharmaceutically acceptable salt thereof.

A novel application of the Ullmann coupling reaction for the alkylsulfenylation of 2-amino-imidazo [1,2-a] pyridine

The Ullmann coupling reaction between the 2-trifluoroacetamido-3-iodo- 6-benzoylimidazo[1,2-a]pyridine and dialkyldisulfides (Me, (i)Pr) mediated by copper bronze in pyridine, resulted in a novel and highly efficient method for the incorporation of alkylt