220657-12-5

Basic information

• Product Name: (S)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxycarbonyl)-ethyl ester
• Synonyms: (S)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxycarbonyl)-ethyl ester
• CAS NO: 220657-12-5
• Molecular Weight: 610.82
• Mol File: 220657-12-5.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxycarbonyl)-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxycarbonyl)-ethyl ester(220657-12-5)
• EPA Substance Registry System: (S)-2-(Benzyloxycarbonyl-methyl-amino)-4-methyl-pentanoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxycarbonyl)-ethyl ester(220657-12-5)

Safety Data

• Hazardous Substances Data: 220657-12-5(Hazardous Substances Data)

Upstream product

• 2018-66-8 Z-Leu-OH 
• 33099-08-0 N-benzyloxycarbonyl-N-methyl-L-leucine 
• 126587-71-1 Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester 

Downstream Products

• 220657-20-5 N--L-leucyl>-L-prolyl>-N-methyl-L-leucine ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-<(tert-butyldimethylsilyl)oxy>... 
• 220657-23-8 N--L-leucyl>-L-prolyl>-N-methyl-L-leucine ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isopropyl-2-(methoxy... 
• 220657-16-9 (S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-4-methyl-pentanoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxycarbonyl)-ethyl ester 
• 185610-65-5 (S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-4-methyl-pentanoic acid (1R,2S)-2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethyl ester 
• 185610-66-6 N--L-leucyl>-L-prolyl>-N-methyl-L-leucine ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3S)-1-isopropyl-2-(methoxymethoxy)-3-... 

Relevant articles and documents

Synthesis and biological activities of [N-MeLeu5]- and [N-MePhe5]- didemnin B

Based on information from X-ray, NMR, and SAR data, the N,O-diMeTyr5 unit of didemnin B was believed to be important for biological activity. To determine the importance of aromaticity and the role of the methoxy group in this unit, two analogs