220664-31-3 Usage
Uses
Used in Pharmaceutical Industry:
METHYL 3-BROMO-1H-INDOLE-2-CARBOXYLATE is used as a key intermediate in the synthesis of arylamide derivatives, which are known as EP4 receptor antagonists. These antagonists play a crucial role in the development of novel therapeutic agents for the treatment of various inflammatory and pain-related conditions. By targeting the EP4 receptor, these compounds can modulate the inflammatory response and provide relief from pain, making them valuable in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 220664-31-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,6,6 and 4 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 220664-31:
(8*2)+(7*2)+(6*0)+(5*6)+(4*6)+(3*4)+(2*3)+(1*1)=103
103 % 10 = 3
So 220664-31-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H8BrNO2/c1-14-10(13)9-8(11)6-4-2-3-5-7(6)12-9/h2-5,12H,1H3
220664-31-3Relevant academic research and scientific papers
Amide derivative and application thereof in preparation of EP4 receptor antagonist
-
Paragraph 0077-0081; 0092-0097, (2021/04/07)
The invention discloses a compound shown as a formula I. The compound can be used as an EP4 receptor antagonist of PGE2, inhibits enzyme and cell proliferation, and is used for treating diseases related to an EP4 receptor, including cancers, inflammatory diseases, pains and other indications.
Indole derivatives as MCP-1 receptor antagonists
-
, (2008/06/13)
The invention concerns pharmaceutically useful indoles of formula (I), in which Z, X, T, A, R1, R2, p and q have any of the meanings defined herein, and their pharmaceutically acceptable salts or in vivo hydrolysable esters, as well
