220690-91-5

Upstream product

• 220691-58-7 (2S,4S)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-3,4-dihydro-2H-pyran-4-ol 
• 220691-14-5 (2S,6S,7S,9S,15R)-15-{(2S,5R,6R,8S)-5-Benzyloxy-8-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-10-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-ylmethyl}-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220691-12-3 (2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220691-62-3 (2S,6S,7S,9S,15R)-15-{(2S,6R,8S)-8-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-10-methyl-5-oxo-1,7-dioxa-spiro[5.5]undec-10-en-2-ylmethyl}-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220691-67-8 (2S,6S,7S,9S,15R)-15-{(2S,5R,6R,8S)-8-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-hydroxy-10-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-ylmethyl}-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220691-71-4 (2S,6S,7S,9S,15R)-15-[(2S,5R,6R,8S)-5-Benzyloxy-8-((R)-2-hydroxy-1-methyl-ethyl)-10-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-ylmethyl]-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220691-03-2 (2S,6S,7S,9S,15R)-15-Methyl-15-((S)-5-oxo-tetrahydro-furan-2-ylmethyl)-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220691-54-3 (2S,6S,7S,9S,15R)-15-((S)-2,5-Dihydroxy-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220691-51-0 (2S,6S,7S,9S,15R)-15-((S)-2-Hydroxy-pent-4-enyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220691-01-0 (2S,6S,7S,9S,15R)-15-Methyl-15-(R)-1-oxiranylmethyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220690-97-1 (2S,6S,7S,9S,15R)-15-Allyl-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220690-96-0 (2S,6R,7S,9S)-2,9-Diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one 
• 220691-09-8 tert-Butyl-[(R)-2-((2S,4S)-4-methoxy-4-methyl-3,4-dihydro-2H-pyran-2-yl)-propoxy]-diphenyl-silane 
• 154859-09-3 (6S,6'S)-6,6'-Diphenyl-5,6,5',6'-tetrahydro-4H,4'H-[2,2']bipyranyl 

Relevant academic research and scientific papers

Total synthesis of the protein phosphatase inhibitor okadaic acid

The total synthesis of the protein phosphatase inhibitor okadaic acid 1 is reported using a convergent coupling strategy of three components, all of which may be prepared using chemistry developed in our laboratories.