220697-60-9Relevant academic research and scientific papers
Highly efficient, mild, one pot synthesis of 2-substituted benzimidazoles, benzothiazoles and pyridoimidazoles promoted by N-iodosuccinimide
Bhattacharyya, Bhaswati,Dhara, Kaliprasanna
, p. 1749 - 1759 (2014/01/17)
A common and highly efficient metal-free route for the synthesis of 2-substituted benzimidazoles, benzothiazoles and pyridoimidazoles from suitable 1,2-difunctionalised aromatic compounds and various aromatic and aliphatic aldehydes and ferrocenecarboxaldehyde was developed using N-iodosuccinimide as the oxidizing agent. The methodology involved very short reaction time, mild reaction procedure and easy work-up as well as excellent yields of the products.
Discovery and preliminary structure-activity relationship of arylpiperazines as novel, brain-penetrant antiprion compounds
Li, Zhe,Gever, Joel R.,Rao, Satish,Widjaja, Kartika,Prusiner, Stanley B.,Silber, B. Michael
supporting information, p. 397 - 401 (2013/06/27)
Creutzfeldt-Jakob disease and kuru in humans, BSE in cattle, and scrapie in sheep are fatal neurodegenerative disorders. Such illnesses are caused by the conversion and accumulation of a misfolded pathogenic isoform (termed PrP Sc) of a normall
