220705-02-2Relevant academic research and scientific papers
Toward the synthesis of novel fluorinated building blocks: 3,4-difluorothiophene-1,1-dioxide
Nowak, Ireneusz,Rogers, Lillian M.,Rogers, Robin D.,Thrashe, Joseph S.
, p. 27 - 31 (2007/10/03)
Addition of elemental fluorine to 2,5-dihydrothiophene-1,1-dioxide (4) provided a mixture of isomeric 3,4-difluoro-2,3,4,5-tetrahydrothiophene-1,1-dioxides (5) in moderate yield. Photochemical chlorination of each of these isomers gave the same product mixture consisting mainly of trans-3-chloro-3,4-difluoro-2,3,4,5-tetrahydrothiophene-1,1-dioxide (9a) and trans-3,4-dichloro-3,4-difluoro-2,3,4,5-tetrahydrothiophene-1,1-dioxide (11b). Dehydrohalogenation of the former gave 3,4-difluoro-4,5-dihydrothiophene-1,1-dioxide (12) as the main product, whereas dehydrohalogenation of the latter gave 3,4-difluorothiophene-1,1-dioxide (3) as the main product.
