220712-46-9Relevant academic research and scientific papers
Synthesis of inositol glycan cyclic phosphates
Jaworek, Christine H.,Iacobucci, Sarah,Calias, Pericles,D'Alarcao, Marc
, p. 375 - 391 (2007/10/03)
An efficient synthesis of tri-, tetra-, and pentasaccharide cyclic phosphates 1-5, structurally related to natural inositol phosphate glycans, is reported. The title compounds were assembled by PhSeOTf-promoted glycosylation of the known glucosamine precu
Synthesis of an inositol-containing trisaccharide related to insulin signal transduction
Jaworek, Christine H.,Calias, Pericles,Iacobucci, Sarah,D'Alarcao, Marc
, p. 667 - 670 (2007/10/03)
A synthesis of D-mannosyl-(α1-4)-D-glucosaminyl-(α1-6)-D-myo-inositol- 1:2-cyclic phosphate (1) from D-xylose, D-mannose, and D-glucal is reported. Compound 1 constitutes the terminal structure of the PI-PLC-released VSG membrane anchor of Trypanosomes and is structurally related to the inositol phosphate glycan implicated as an insulin second messenger in higher organisms.
