220728-62-1

Basic information

• Product Name: 4-IODO-2-METHOXYTOLUENE
• Synonyms: 4-Iodo-2-methoxy-1-methyl-benzene
• CAS NO: 220728-62-1
• Molecular Formula: C₈H₉IO
• Molecular Weight: 248.0609
• Product Categories: Aromatic Halides (substituted)
• Mol File: 220728-62-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 255.2 °C at 760 mmHg
• Flash Point: 108.2 °C
• Appearance: /
• Density: 1.634 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-IODO-2-METHOXYTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-2-METHOXYTOLUENE(220728-62-1)
• EPA Substance Registry System: 4-IODO-2-METHOXYTOLUENE(220728-62-1)

Safety Data

• Hazardous Substances Data: 220728-62-1(Hazardous Substances Data)

Usage

General Description

4-Iodo-2-methoxytoluene is a chemical compound with the molecular formula C8H9IO. It is an iodine substituted derivative of 2-methoxytoluene, which is also known as o-cresol. It is a colorless to pale yellow liquid with a strong odor. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis. 4-Iodo-2-methoxytoluene is considered to be a hazardous substance and should be handled with care due to its potential health and environmental risks.

Upstream product

• 762-72-1 allyl-trimethyl-silane 
• 16452-01-0 ortho-cresidine 

Downstream Products

• 1122012-31-0 5-(3-methoxy-4-methylphenyl)pentanal 
• 220728-68-7 2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene 
• 220728-76-7 Acetic acid (S)-3-methoxymethoxy-2-(3-methoxy-4-methyl-phenyl)-propyl ester 
• 220728-49-4 (S)-2-methoxy-1-methyl-4-(1-(phenylsulfonyl)propan-2-yl)benzene 
• 220728-57-4 Acetic acid (S)-3-hydroxy-2-(3-methoxy-4-methyl-phenyl)-propyl ester 
• 220728-73-4 Acetic acid (R)-3-hydroxy-2-(3-methoxy-4-methyl-phenyl)-propyl ester 
• 220728-66-5 (R)-3-Methoxymethoxy-2-(3-methoxy-4-methyl-phenyl)-propan-1-ol 
• 220728-77-8 2-Methoxy-1-methyl-4-((S)-1-methyl-2-phenylsulfanyl-ethyl)-benzene 
• 220728-59-6 2-(3-methoxy-4-methyl-phenyl)-propane-1,3-diol 
• 220728-54-1 (S)-2-(3-methoxy-4-methylphenyl)propan-1-ol 
• 30199-27-0 (R)-2-methoxy-1-methyl-4-(6-methylhept-5-en-2-yl)benzene 
• 59684-62-7 (R)-(-)-xanthorrhizol 
• 220728-63-2 2-tert-butyl-5-(3-methoxy-4-methyl-phenyl)-4,5-dihydro-[1,3]dioxepine 

Relevant articles and documents

Synthesis of complex ortho-allyliodoarenes by employing the reductive iodonio-claisen rearrangement

The reductive iodonio-Claisen rearrangement (RICR), involving complex aromatic λ3-iodanes and allyltrimethylsilane, was investigated. The RICR reaction of complex substituted aromatic hypervalent iodine (III) compounds and an allylmetal partner was conducted. The anionic oxy Cope rearrangement was found to be approximately 1010 to 1017 times faster than the neutral oxy Cope rearrangement due to weakening of the adjacent C-C bond by the oxygen anion. The results also indicate that the steric and electronic nature of the aromatic λ3-iodanes is the dominant factor influencing the [3,3]-sigmatropic rearrangement reaction. The removal of tert-butyl ether protecting group by using trifluroacetic acid in dichloromethane in the presence of triisopropylsilane gives the natural product broussin in 39% yield.