220741-56-0

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 71026-66-9 N-(tert-butoxycarbonyl)-1,4-phenylenediamine 
• 501-53-1 benzyl chloroformate 
• 82720-42-1 (4-Amino-phenyl)-carbamic acid benzyl ester 
• 4248-19-5 tert-butyl carbazate 
• 621-84-1 O-benzyl carbamate 
• 131818-17-2 tert-butyl (4-bromophenyl)carbamate 
• 589-87-7 1,4-bromoiodobenzene 

Downstream Products

• 82720-42-1 (4-Amino-phenyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Simple and efficient method for n-boc protection of amines using PEG-400 as a reaction medium under mild conditions

Simple and efficient method for N-Boc protection of amines using PEG-400 as an ecofriendly reaction medium at room temperature is described. Various aromatic, heteroaromatic, and aliphatic amines were converted to the corresponding N-tert-butyl-carbamates in good to excellent yields in short times.

Installation of protected ammonia equivalents onto aromatic & heteroaromatic rings in water enabled by micellar catalysis

A single set of conditions consisting of a palladium catalyst, a commercially available ligand, and a base, allow for several types of C-N bond constructions to be conducted in water with the aid of a commercially available "designer" surfactant (TPGS-750-M). Products containing a protected NH2 group in the form of a carbamate, sulfonamide, or urea can be fashioned starting with aryl or heteroaryl bromides, iodides, and in some cases, chlorides, as substrates. Reaction temperatures are in the range of room temperature to, at most, 50 °C, and result in essentially full conversion and good isolated yields.

Chemoselective conversion of azides to t-butyl carbamates and amines

Azides were converted to the corresponding carbamates using a system of 20 mol% of decaborane (B10H14) and 20 weight% of 10% Pd/C in methanol in the presence of di-tert-butyl dicarbonate at rt in high yields and to the corresponding amines using a system of 10 mol% of decaborane and 20 weight% of 10% Pd/C in methanol in the absence of di-tert-butyl dicarbonate at rt in high yields.

Aniline derivatives as calcium channel blockers

The present invention provides compounds that block calcium channels having formula (I). The present invention also provides methods of using the compounds of formula (I) to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of formula (I).