220792-00-7Relevant academic research and scientific papers
Oxidative amination of cuprated pyrimidine and purine derivatives
Boudet, Nadege,Dubbaka, Srinivas Reddy,Knochel, Paul
supporting information; experimental part, p. 1715 - 1718 (2009/04/10)
Using regioselective cuprations (via magnesiations), various primary, secondary and tertiary aminated pyrimidine and purine derivatives were prepared by the oxidative coupling of lithium amidocuprates using chloranil. DNA and RNA units such as aminated uracil or thymine, and adenine, as well as a CDK inhibitor, purvalanol A, were all obtained under mild conditions and satisfactory yields.
