220802-72-2

Upstream product

• 220802-60-8 benzyl 4-methyl-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrole-2-carboxylate 
• 380231-99-2 benzyl 5-acetoxymethyl-3-methyl-4-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrole-2-carboxylate 
• 40236-19-9 benzyl 3,5-dimethylpyrrole-2-carboxylate 
• 205492-38-2 benzyl 3,5-dimethyl-4-(trifluoroacetyl)pyrrole-2-carboxylate 
• 220802-58-4 methyl 3-((S)-1-acetoxy-2,2,2-trifluoroethyl)-4-methylpyrrole-2-carboxylate 
• 220802-56-2 methyl 4-((S)-1-acetoxy-2,2,2-trifluoroethyl)-2-iodo-3-methylpyrrole-5-carboxylate 
• 220802-54-0 4-((S)-1-acetoxy-2,2,2-trifluoroethyl)-5-methoxycarbonyl-3-methylpyrrole-2-carboxylic acid 
• 220802-47-1 benzyl 4-((S)-1-acetoxy-2,2,2-trifluoroethyl)-3,5-dimethylpyrrole-2-carboxylate 
• 220802-52-8 benzyl 4-((S)-1-acetoxy-2,2,2-trifluoroethyl)-5-methoxycarbonyl-3-methylpyrrole-2-carboxylate 
• 220802-50-6 3-(1-acetoxy-2,2,2-trifluoro-ethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 

Relevant academic research and scientific papers

Syntheses of chiral fluorine analogs of hematoporphyrin

Four chiral fluorine analogs of hematoporphyrin, (R,R)-, (R,S)-, (S,R)-, and (S,S)-3,8-bis(2,2,2-trifluoro-1-hydroxyethyl)deuteroporphyrins, were synthesized starting from pyrroles with a chiral 2,2,2-trifluoro-1-hydroxyethyl (TFHE) group. This chiral TFHE group was obtained by asymmetric reduction of a trifluoroacetyl group. Among these chiral analogs of hematoporphyrin, the (S,S)-isomer showed higher affinity for cancer cells than other stereoisomers.