22082-41-3Relevant academic research and scientific papers
Ruthenium-catalyzed cyclic carbonylation of allenyl alcohols. Selective synthesis of γ- and δ-lactones
Yoneda, Eiji,Kaneko, Takayuki,Zhang, Shi-Wei,Onitsuka, Kiyotaka,Takahashi, Shigetoshi
, p. 441 - 443 (2007/10/03)
(Formula presented) Ruthenium complex-catalyzed carbonylation of allenyl alcohols quantitatively gave cyclic carbonyl compounds, γ- and δ-lactones, in which the hydroxy group of allenyl alcohols participated in the cyclization. A wide variety of allenyl alcohols, such as mono-, di-, and trisubstituted alcohols, can be used in this reaction to produce 3- and 4-substituted γ-lactones. Similarly, the cyclic carbonylation of 3,4-pentadien-1-ol 10a and 2-methyl-4,5-hexadien-2-ol 11a gave δ-lactones, 5,6-dihydro-3-methyl-2H-pyran-2-one 10b, and 5,6-dihydro-6,6-dimethyl-3-methyl-2H-pyran-2-one 11b, respectively, in a quantitative yield.
