220873-35-8

Upstream product

• 1215-59-4 5-benzyloxy-1H-indole 
• 102147-52-4 N-benzyloxymethyl-3,4-dibromomaleimide 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 220873-38-1 1-Benzyloxymethyl-3-[5-benzyloxy-1-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-1H-indol-3-yl]-4-bromo-pyrrole-2,5-dione 
• 220873-41-6 3-(5-Benzyloxy-1H-indol-3-yl)-1-benzyloxymethyl-4-[5-benzyloxy-1-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-1H-indol-3-yl]-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Indolocarbazole anticancer agents and methods of using same

The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of the following general formulas that inhibit topoisomerase I activity. 1

Indolocarbazole anticancer agents and methods of using them

The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of the following general formulas that inhibit topoisomerase I activity. 1

Indolocarbazole poisons of human topoisomerase I: Regioisomeric analogues of ED-110

All four 'symmetrical' regioisomers of ED-110, an indolocarbazole derivative having potent activity against human topoisomerase I (Topo I) were synthesized. The isomer containing hydroxyl groups in the 3- and 9-positions was approximately ten-fold more active against Topo I, and 5- to 35-fold more active against human solid tumor cell lines in vitro, relative to ED-110.