220875-99-0

Upstream product

• 824-98-6 m-methoxybenzyl chloride 
• 5453-85-0 ethyl cyclopentanecarboxylate 
• 90110-63-7 3-methoxybenzyl iodide 
• 4630-80-2 methyl cyclopentane carboxylate 
• 220875-91-2 1-(3-methoxy-benzyl)-cyclopentanecarboxylic acid methyl ester 

Relevant academic research and scientific papers

Allylamine derivative as well as preparation method and application thereof

The invention relates to an allylamine derivative as well as a preparation method and application thereof, and in particular, relates to a compound represented by a formula I, or a stereoisomer, a tautomer, a polymorphic substance, a solvate, an N-oxide, an isotope labeled compound, a metabolite, a prodrug or ester thereof, or a pharmaceutically acceptable salt thereof. The compound has a higher inhibitory activity against vascular adhesion protein 1/semicarbazide sensitive amine oxidase, a good selectivity against monoamine oxidase and diamine oxidase; and additionally, in some embodiments, the mixture has a high in vivo bioavailability as well as safety.

N-Cycloalkanoyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.

A systematic structure-activity relationship investigation of the lead compound 1 resulted the identification of several N-[(substituted alkyl)cycloalkanoyl]-4-[((2,6-dichlorophenyl)carbonyl)amino]-L-phenylalanine derivatives as potent VCAM/VLA-4 antagonists. The data are consistent with a model of these compounds in which these alkanoylphenylalanines reside in a compact gauche (-) bioactive conformation.