220911-76-2

Upstream product

• 111-87-5 octanol 
• 112289-38-0 1,2-anhydro-3,4,6-tri-O-benzyl-D-galactopyranose 
• 283587-72-4 octyl 2-O-acetyl-3,4,6-tri-O-benzyl-β-D-galactopyranoside 

Downstream Products

• 283587-88-2 octyl 2,3,4-tri-O-benzyl-β-D-arabinopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 
• 283587-76-8 Thiocarbonic acid O-[(2S,3R,4R,5S,6S)-4,5-bis-benzyloxy-6-((2R,3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-octyloxy-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-3-yl] ester O-pentafluorophenyl ester 
• 283587-81-5 Thiocarbonic acid O-[(2S,3S,4R,5R,6S)-3,5-bis-benzyloxy-2-((2R,3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-octyloxy-tetrahydro-pyran-3-yloxy)-6-methyl-tetrahydro-pyran-4-yl] ester O-pentafluorophenyl ester 
• 283587-86-0 Thiocarbonic acid O-[(2S,3S,4R,5R,6S)-4,5-bis-benzyloxy-2-((2R,3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-octyloxy-tetrahydro-pyran-3-yloxy)-6-methyl-tetrahydro-pyran-3-yl] ester O-pentafluorophenyl ester 
• 283587-79-1 octyl 2,4-di-O-benzyl-α-L-fucopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 
• 283587-84-8 octyl 3,4-di-O-benzyl-α-L-fucopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 
• 283587-74-6 octyl 2,3-di-O-benzyl-α-L-fucopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 
• 283587-80-4 octyl 2,4-di-O-benzyl-3-O-methyl-α-L-fucopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 
• 283587-85-9 octyl 3,4-di-O-benzyl-2-O-methyl-α-L-fucopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 
• 283587-75-7 octyl 2,3-di-O-benzyl-4-O-methyl-α-L-fucopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 
• 283587-87-1 octyl 3,4-di-O-benzyl-α-L-xylo-hexopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 
• 283587-82-6 octyl 2,4-di-O-benzyl-α-L-xylo-hexopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 
• 283587-77-9 octyl 3,4,6-tri-O-benzyl-2-O-(2,3-di-O-benzyl-α-L-xylo-hexopyranosyl)-(1->2)-β-D-galactopyranoside 
• 283587-83-7 octyl 3,4-di-O-benzyl-2-O-p-methoxybenzyl-α-L-fucopyranosyl-(1->2)-3,4,6-tri-O-benzyl-β-D-galactopyranoside 

Relevant academic research and scientific papers

Regio- and stereoselective β-mannosylation using a boronic acid catalyst and its application in the synthesis of a tetrasaccharide repeating unit of lipopolysaccharide derived from E. coli O75

Regio- and stereoselective β-mannosylations using 1,2-anhydromannose and diol sugar acceptors in the presence of a boronic acid catalyst proceeded smoothly to give the corresponding β-mannosides with high regio- and β-stereoselectivities in high yields without further additives under mild conditions. In addition, this glycosylation method was applied successfully to the synthesis of a tetrasaccharide repeating unit of lipopolysaccharide (LPS) derived from E. coli O75.

Synthesis and enzymatic evaluation of modified acceptors of recombinant blood group A and B glycosyltransferases

The disaccharide α-L-Fucp-(1→2)-β-D-Galp-(1→O)-Octyl (1) is an acceptor for the human blood group A and B glycosyltransferases. Seven analogues of 1, containing deoxy, methoxy and arabino modifications of the Fuc residue, were chemically synthesized and kinetically evaluated in radioactive enzymatic assays. Both the enzymes tolerate modification of the 3'-OH on the fucose residue. The 2'-OH was found to be key to the recognition of the acceptors by these enzymes. The arabino derivative was recognized as an acceptor by the A transferase (K(m) of 200 μM), but not the B transferase and is the first synthetic acceptor capable of distinguishing between the two enzyme activities. (C) 2000 Elsevier Science Ltd.