22092-21-3Relevant academic research and scientific papers
Preparation of acid-labile resins with halide linkers and their utility in solid phase organic synthesis
Ngu, Khehyong,Patel, Dinesh V.
, p. 973 - 976 (2007/10/03)
Mild and efficient preparation of acid-labile resins with displaceable halide linkers (3 and 4, X = Br and I) is described. These resins can be used in combinatorial organic synthesis of numerous drug-scaffold libraries. Their synthetic utility is exemplified by high yielding N-alkylations with structurally and electronically diverse sets of aliphatic and aromatic amines. Amongst the various resins modified and evaluated in this study, Wang resin derived bromo resin (3, X = Br) offers the best practical choice with respect to loading, stability, and chemical reactivity.
