220929-54-4Relevant academic research and scientific papers
Efficient synthesis of substituted cyclic α-aminophosphonates
Odinets, Irina L.,Artyushin, Oleg I.,Shevchenko, Nikolay,Petrovskii, Pavel V.,Nenajdenko, Valentin G.,Roeschenthaler, Gerd-Volker
experimental part, p. 577 - 582 (2009/07/18)
The addition of diethyl phosphite to cyclic imines bearing alkyl, aryl, or heteroaryl substituents at the α-position in diethyl ether at room temperature presents an efficient route to substituted cyclic α-aminophosphonates. The application of boron trifl
Linear or cyclic aminophosphonates as pH markers in phosphorus 31 NMR spectroscopy
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, (2008/06/13)
Linear or cyclic aminophosphonates are disclosed which are useful as pH markers. A method of using the linear or cyclic aminophosphonates in phosphorus-31 NMR spectroscopy is also disclosed.
Synthesis of a new spin trap: 2-(diethoxyphosphoryl)-2-phenyl-3,4-dihydro-2H-pyrrole 1-oxide
Karoui, Hakim,Nsanzumuhire, Celine,Le Moigne, Francois,Tordo, Paul
, p. 1471 - 1477 (2007/10/03)
Recently, the synthesis of a new phosphorylated nitrone, 2-(diethoxyphosphoryl)-2-methyl-3,4-dihydro-2H-pyrrole 1-oxide (DEPMPO) (2) was described. The presence of the phosphorylated group strongly stabilized the DEPMPO-superoxide spin adduct. To understand the role of the diethoxy-phosphoryl group in this stabilization, a new phosphorylated nitrone, 2-(diethoxyphosphoryl)-2-phenyl-3,4-dihydro-2H-pyrrole 1-oxide (DEPPPO) (7), was prepared through a four-step synthetic pathway, and its ability to trap free radicals was investigated. Data obtained from spin trapping experiments of a wide variety of free radicals generated in situ showed the formation of two diastereoisomers spin adducts with different phosphorus and hydrogen coupling constants. Superoxide trapping by DEPPPO gave a persistent nitroxide spin adduct, and its half-time life was measured and compared to that of the DEPMPO analogue.
