220935-98-8

Upstream product

• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 31756-16-8 6,7-dimethoxy-2-veratryl-3,4-dihydro-isoquinolinium; chloride 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 76800-86-7 6,7-dimethoxy-2-veratryl-1,2,3,4-tetrahydro-isoquinoline-1-carbonitrile 

Downstream Products

• 220935-99-9 2-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

(±)-Heterocarpine, a hydroxymethylated isoquinoline alkaloid from Ceratocapnos heterocarpa

Heterocarpine, a novel alkaloid from Ceratocapnos heterocarpa, has been characterised as (±)-1-hydroxymethyl-2-(3-hydroxy-4-methoxybenzyl)-7- hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline. The alkaloid was synthesized from the corresponding 3,4-dihydro isoquinoliniun salt. A key step in the process is the acid resin catalysed methanolysis of the 1- carbamoyl isoquinoline. The structural correlation of the hydroxymethylated alkaloids heterocarpine and malacitanine with their unsubstituted counterparts capnosine and caseamine, also present in the plant, might be of biosynthetic significance.