220936-12-9Relevant articles and documents
Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited rabggtase
Deraeve, Celine,Guo, Zhong,Bon, Robin S.,Blankenfeldt, Wulf,DiLucrezia, Raffaella,Wolf, Alexander,Menninger, Sascha,Stigter, E. Anouk,Wetzel, Stefan,Choidas, Axel,Alexandrov, Kirill,Waldmann, Herbert,Goody, Roger S.,Wu, Yao-Wen
supporting information; experimental part, p. 7384 - 7391 (2012/06/30)
Post-translational attachment of geranylgeranyl isoprenoids to Rab GTPases, the key organizers of intracellular vesicular transport, is essential for their function. Rab geranylgeranyl transferase (RabGGTase) is responsible for prenylation of Rab proteins
Calcilytic compounds
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, (2008/06/13)
Novel calcilytic compounds, pharmaceuticals compositions cotaining said compounds and their use as calcium receptor antagonists.