22094-62-8

Usage

Uses

Used in Chemical Industry:
6-Aminosaccharin is used as a key component in the production of dyes and pigments for its versatile chemical properties.
Used in Medicine:
6-Aminosaccharin is used as a pharmaceutical compound for its potential applications in medical research and development, despite its hazardous nature.
Used in Agriculture:
6-Aminosaccharin is used as a chemical in agricultural applications, possibly for its effects on plant growth or as a component in agrochemicals.
Used in Scientific Research:
6-Aminosaccharin is used as a research tool in various scientific studies, taking advantage of its unique structural and chemical properties.

InChI:InChI=1/C7H6N2O3S/c8-4-1-2-5-6(3-4)13(11,12)9-7(5)10/h1-3H,8H2,(H,9,10)

Upstream product

• 99-99-0 1-methyl-4-nitrobenzene 
• 121-02-8 2-methyl-5-nitrobenzene-1-sulfonyl chloride 
• 6269-91-6 4-nitrotoluene-2-sulfonamide 
• 22952-24-5 6-nitrosaccharin 

Downstream Products

• 84591-91-3 6-<4-(2-bromoethyl)benzenesulfonamido>saccharin 
• 1374832-67-3 6-(N₃-(2-fluorophenyl)ureido)saccharin 
• 1374832-81-1 6-(N₃-(3-fluorophenyl)thioureido)saccharin 
• 1374832-85-5 6-(N₃-(3-iodophenyl)thioureido)saccharin 
• 1374832-59-3 6-(N₃-(4-chlorophenyl)ureido)saccharin 
• 1374832-65-1 6-(N₃-(4-nitrophenyl)ureido)saccharin 
• 1374832-79-7 6-(N₃-(2-fluorophenyl)thioureido)saccharin 
• 1374832-49-1 6-(N₃-phenylureido)saccharin 
• 1374832-73-1 6-(N₃-phenylthioureido)saccharin 
• 1374832-55-9 6-(N₃-(4-methylphenyl)ureido)saccharin 
• 1374832-71-9 6-(N₃-(4-fluorophenyl)ureido)saccharin 
• 1374832-53-7 6-(N₃-(4-methoxyphenyl)ureido)saccharin 
• 1374832-77-5 6-(N₃-(4-methoxyphenyl)thioureido)saccharin 
• 1374832-61-7 6-(N₃-(3,4-dichlorophenyl)ureido)saccharin 

Relevant academic research and scientific papers

A convenient synthesis of 2-methoxycarbonyl-5-iodobenzene sulfonamide

A convenient and concise synthesis of 2-methyl-5-nitrobenzene sulfonamide can be achieved by sulfochlorination and ammoniation with p-nitrotoluene as raw materials for an 81.2 % yield. 6-Aminosaccharin can be produced via oxidation and reduction in a 64.3

In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase i and II

In this study, in vitro inhibitory effects of some saccharin derivatives on purified carbonic anhydrase I and II were investigated using CO2 as a substrate. The results showed that all compounds inhibited the hCA I and hCA II enzyme activities. Among the compounds, 6-(p-tolylthiourenyl) saccharin (6m) was found to be the most active one for hCA I activity (IC50 = 13.67 μM) and 6-(m-methoxyphenylurenyl) saccharin (6b) was found to be the most active one for hCA II activity (IC50 = 6.54 μM). Structure-activity relationships (SARs) study showed that, generally, thiourea derivatives (6l - v) inhibited more hCA I and hCA II than urea derivatives (6a-k). All compounds (excluding 6c and 6r) have higher inhibitory activity on hCA II than on hCA I.

Design, synthesis and preliminary bioactivity studies of 1,2-dihydrobenzo[d]isothiazol-3-one-1,1-dioxide hydroxamic acid derivatives as novel histone deacetylase inhibitors

Histone deacetylase (HDAC) is a clinically validated target for antitumor therapy. In order to increase HDAC inhibition and efficiency, we developed a novel series of saccharin hydroxamic acids as potent HDAC inhibitors. Among them, compounds 11e, 11m, 11

FURO[3,2-d]PYRIMIDINE COMPOUNDS

The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

New saccharin derivatives as tyrosinase inhibitors

A newly series of 6-(phenylurenyl/thiourenyl) saccharin (6a-y) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. A 70-fold purification of the enzyme with 6.85% yield was achieved by using a Sepharose 4B-l-tyrosine-p-amino benzoic acid affinity column. The result showed that all the synthesized compounds inhibited the tyrosinase enzyme activity. Among the compounds synthesized, 6-(3-iodophenylthiourenyl) saccharin (6s) was found to be most active one (Ki = 3.95 μM) and the inhibition kinetics analyzed by Lineweaver-Burk double reciprocal plots revealed that compound 6s was a competitive inhibitor. Structure-activity relationships study showed that generally, most of the 6-(phenylthiourenyl) saccharin derivatives (6m-y) exhibited higher inhibitory activity than 6-(phenylurenyl) saccharin derivatives (6a-l). An electron-withdrawing group at 3-position of phenylurenyl-ring increased in activity and the halogen series at 3-position of phenylthiourenyl-ring showed a qualitative relationship for higher inhibitory activity with increasing size and polarizability. We also calculated HOMO-LUMO energy levels and dipole moments of some selected the synthesized compounds (6a, 6h, 6m and 6s) using Gaussian software.

PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS

A compound of formula (I) or a salt or solvate thereof: Formula (1) compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such mono-anilino pyrimidine derivative