220969-61-9

Basic information

• Product Name: (1R,3R)-(N-benzyl-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-O-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate
• Synonyms: (1R,3R)-(N-benzyl-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-O-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate
• CAS NO: 220969-61-9
• Molecular Weight: 588.541
• Mol File: 220969-61-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,3R)-(N-benzyl-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-O-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3R)-(N-benzyl-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-O-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate(220969-61-9)
• EPA Substance Registry System: (1R,3R)-(N-benzyl-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-O-yl) 1'-bromo-5'-isopropoxy-4'-methoxy-2'-naphthoate(220969-61-9)

Safety Data

• Hazardous Substances Data: 220969-61-9(Hazardous Substances Data)

Upstream product

• 129519-18-2 (1R,3R)-2-Benzyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-ol 
• 202215-69-8 1-bromo-5-isopropoxy-4-methoxy-2-naphthoic acid 

Downstream Products

• 220969-63-1 N-benzyldioncolactone A 
• 220969-62-0 N-benzyl-5'-O-isopropyldioncolactone A 

Relevant articles and documents

Directed joint total synthesis of the three naphthylisoquinoline alkaloids dioncolactone A, dioncopeltine A, and 5'-O-demethyldioncophylline A

The first total synthesis of the three antimalarial naphthylisoquinoline alkaloids dioncolactone A (4), dioncopeltine A (5), and 5'-O- demethyldioncophylline A (6) is described. The regio- and stereoselective construction of the biaryl axes was achieved through the 'lactone methodology', by ester-type prefixation of the two molecular moieties, intramolecular coupling, and atropo-diastereoselective cleavage of the lactone auxiliary bridge. As a novel alternative, the configuration at the axis may be installed by atroposelective hydroxy aldehyde reduction through dynamic kinetic resolution.