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5-Ethyl-1,3-dihydro-1-(2,3,5,6-tetrafluorophenyl)-2H-indol-2-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 220991-61-7 Structure
  • Basic information

    1. Product Name: 5-Ethyl-1,3-dihydro-1-(2,3,5,6-tetrafluorophenyl)-2H-indol-2-one
    2. Synonyms: 5-Ethyl-1,3-dihydro-1-(2,3,5,6-tetrafluorophenyl)-2H-indol-2-one
    3. CAS NO:220991-61-7
    4. Molecular Formula: C16H11F4NO
    5. Molecular Weight: 309.2582528
    6. EINECS: N/A
    7. Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 220991-61-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 473.7±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.406±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: -5.48±0.20(Predicted)
    10. CAS DataBase Reference: 5-Ethyl-1,3-dihydro-1-(2,3,5,6-tetrafluorophenyl)-2H-indol-2-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-Ethyl-1,3-dihydro-1-(2,3,5,6-tetrafluorophenyl)-2H-indol-2-one(220991-61-7)
    12. EPA Substance Registry System: 5-Ethyl-1,3-dihydro-1-(2,3,5,6-tetrafluorophenyl)-2H-indol-2-one(220991-61-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 220991-61-7(Hazardous Substances Data)

220991-61-7 Usage

Uses

Intermediate in the preparation of COX-2 cyclooxygenase inhibitors.

Check Digit Verification of cas no

The CAS Registry Mumber 220991-61-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,9,9 and 1 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 220991-61:
(8*2)+(7*2)+(6*0)+(5*9)+(4*9)+(3*1)+(2*6)+(1*1)=127
127 % 10 = 7
So 220991-61-7 is a valid CAS Registry Number.

220991-61-7Relevant articles and documents

Preparation method of robencoxib intermediate

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Paragraph 0049-0063, (2021/04/21)

The invention relates to a preparation method of a robencoxib intermediate, and belongs to the technical field of pharmacy. The preparation method disclosed by the invention comprises the following step of: reacting a compound R1-RBC04 in the presence of

Preparation method of robecoxib

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Paragraph 0033; 0038-0039; 0043; 0048-0049; 0052; 0057-0058, (2020/11/02)

The invention relates to a preparation method of robecoxib. The preparation method comprises the following steps: under the protection of inert gas, adding 5-ethylindole-2-ketone, 2, 3, 5, 6-tetrafluoroiodobenzene, a catalyst, alkali, a ligand and a solve

Method for preparing robenacoxib

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Paragraph 0024-0026; 0029-0031; 0034-0036; 0039-0041, (2019/04/04)

The invention belongs to the technical field of production of non-steroidal anti-inflammatory drugs and relates to a method for preparing robenacoxib. The method specifically comprises the following steps: (1) in the presence of nitrogen, adding a solvent

Removal of heavy metals from organic reaction mixtures: Preparation and application of functionalized resins

Barbaras, Damien,Brozio, Joerg,Johannsen, Ib,Allmendinger, Thomas

scheme or table, p. 1068 - 1079 (2010/04/22)

Using a toolbox, sulfur and amine ligands are attached to a variety of hydrophobic and hydrophilic resins, and the combinations were tested for the removal of heavy metals from a number of products, prepared by metal-catalyzed reactions. As a result, cheap combinations of silica resins and simple polyamines proved to be among the most effective metal scavengers particularly in apolar solvents such as cyclohexane. Expensive cyclic polyamines are not suitable, owing to kinetic retardation of complexation. Functionalized PEGbased polymers, originally designed for solid phase synthesis, show promising performance as metal scavengers. The results are discussed and compared to alternative approaches for purification such as salt-formation and chemical downstream transformation.

Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives

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, (2008/06/13)

Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1is chloro or fluoro; R2is hydrogen or fluoro; R3is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4is hydrogen or fluoro; and R5is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.

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