220995-81-3

Basic information

• Product Name: 4-bromo-4'-demethyl-epipodophyllotoxin
• Synonyms: 4-bromo-4'-demethyl-epipodophyllotoxin
• CAS NO: 220995-81-3
• Molecular Weight: 463.282
• Mol File: 220995-81-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-bromo-4'-demethyl-epipodophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-4'-demethyl-epipodophyllotoxin(220995-81-3)
• EPA Substance Registry System: 4-bromo-4'-demethyl-epipodophyllotoxin(220995-81-3)

Safety Data

• Hazardous Substances Data: 220995-81-3(Hazardous Substances Data)

Upstream product

• 1014671-32-9 4'-de-O-methylpodophyllotoxin 
• 518-28-5 podofilox 

Downstream Products

• 117604-05-4 4β-azido-4-deoxy-4′-demethylepipodophyllotoxin 
• 117507-84-3 (5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one 
• 125670-69-1 4β-(4''-(2'',2'',6'',6''-tetramethyl-1''-piperidinooxyl))amino-4'-demethylepipodophyllotoxin 
• 6559-91-7 4'-demethylepipodophyllotoxin 

Relevant articles and documents

A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecular hydrogel formation for the drug combination

Making full use of the undeveloped bioactive natural product derivatives by selectively delivering them to target sites can effectively increase their druggability and reduce the wastage of resources. Azo-based prodrugs are widely regarded as an effective targeted delivery means for colon-related disease treatment. Herein, we report a new-type of azo-based nanoprodrug obtained from bioactive natural products, in which the readily available podophyllotoxin natural products are connected with methoxy polyethylene glycol (mPEG)viaa multifunctional azobenzene group. The amphiphilic prodrug can form nanosized micelles in water and will be highly selectively activated by azoreductases, leading to thein situgeneration of anticancer podophyllotoxin derivatives (AdP) in the colon after the cleavage of the azo bond. To satisfy the demand of drug carriers for cancer combination therapy in clinics, α-CD is further introduced into this nanoprodrug micelle system to form a supramolecular hydrogelviaa cascade self-assembly strategy. Using imaging mass spectrometry (IMS), the colon-specific drug release ability of the hydrogel after oral administration is demonstrated at the molecular level. Finally, the nanoprodrug hydrogel is further used as a carrier to load a hydrophilic anti-cancer drug 5-FU during the hierarchical self-assembly process and to co-deliverAdPand 5-FU for the drug combination. The combination use ofAdPand 5-FU provides enhanced cytotoxicity which indicates a significant synergistic interaction. This work offers a new way to enhance the therapeutic effect of nanoprodrugsviadrug combination, and provides a new strategy for reusing bioactive natural products and their derivatives.

A facile and efficient synthesis of 4β-aminopodophyliotoxins

4β-amino-4-desoxypodophyllotoxin and 4β-amino-4'-desmethyl-4- desoxypodophyllotoxin have been synthesized by reduction of the corresponding 4β-azidopodophyllotoxin derivatives with samarium diiodide in excellent yields under convenient and mild conditions.