221013-29-2

Upstream product

• 221013-09-8 1-chloro-4-(methylsulfinylmethoxymethyl)benzene 
• 873-76-7 para-Chlorobenzyl alcohol 
• 88023-84-1 (4-chlorobenzyl)methyl thiomethyl ether 

Downstream Products

• 14289-63-5 1-chloro-4-(2-propenyloxymethyl)benzene 

Relevant academic research and scientific papers

Monofluoromethyl-Substituted Sulfonium Ylides: Electrophilic Monofluoromethylating Reagents with Broad Substrate Scopes

Two electrophilic monofluoromethylating reagents, monofluoromethyl(phenyl)sulfonium bis(carbomethoxy)methylide (3 a) and monofluoromethyl(4-nitrophenyl)sulfonium bis(carbomethoxy)methylide (3 b), and their reactions under mild conditions with a variety of nucleophiles, such as alcohols and malonate derivatives, sulfonic and carboxylic acids, phenols, amides, and N heteroarenes, are described. Mechanistic studies with deuterated reagents [D2]3 a/[D2]3 b suggest that these monofluoromethylation reactions proceed through an electrophilic substitution pathway.

Synthesis and nucleophilic substitution reactions of mono α-fluoro ethers

Mono α-fluoro ethers have been prepared by cleavage of α-alkoxy sulfoxides with diethylaminosulfur trifluoride (DAST) and by an exchange reaction of the corresponding α-chloro ether with tetrabutylammonium fluoride (TBAF). The reactivity of different α-fluoro ethers in some nucleophilic substitution reactions has been investigated. Copyright Acta Chemica Scandinavica 1999.