22102-76-7Relevant articles and documents
Preparation method of creatin-D3
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Paragraph 0032-0036, (2021/11/06)
The invention relates to a preparation method of creatin-D3. The preparation method comprises the following steps of: (1) carrying out amidation reaction on a compound SM-1 and a compound SM-2 to obtain a compound IM-1; (2) carrying out esterification reaction on the compound IM-1 and a compound SM-3 to obtain a compound IM-2; (3) carrying out methylation reaction on the compound IM-2 and a deuterated methylation reagent to obtain a compound IM-3; and (4) removing a protecting group from the compound IM-3 to obtain the creatine-D3. According to the preparation method, raw materials are cheap and easy to obtain, reaction conditions are mild, operation is convenient, and the obtained product has high yield and purity.