221025-38-3Relevant academic research and scientific papers
Imidazo[1,2-a]pyrazine, Imidazo[1,5-a]quinoxaline and?Pyrazolo[1,5-a]quinoxaline derivatives as IKK1 and IKK2 inhibitors
Patinote, Cindy,Bou Karroum, Nour,Moarbess, Georges,Deleuze-Masquefa, Carine,Hadj-Kaddour, Kamel,Cuq, Pierre,Diab-Assaf, Mona,Kassab, Issam,Bonnet, Pierre-Antoine
, p. 909 - 919 (2017/07/27)
The transcription nuclear factor NF-κB plays a pivotal role in chronic and acute inflammatory diseases. Among the several and diverse strategies for inhibiting NF-κB, one of the most effective approach considered by the pharmaceutical industry seems to be
In vitro and in vivo anti-tumoral activities of imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline derivatives
Moarbess, Georges,Deleuze-Masquefa, Carine,Bonnard, Vanessa,Gayraud-Paniagua, Stephanie,Vidal, Jean-Remi,Bressolle, Francoise,Pinguet, Frederic,Bonnet, Pierre-Antoine
, p. 6601 - 6610 (2008/12/22)
Imidazoquinoxaline and pyrazoloquinoxaline derivatives, analogues of imiquimod, were synthesized, and their in vitro cytotoxic and pharmacodynamic activities were evaluated. In vitro cytotoxicity studies were assessed against melanoma (A375, M4Be, RPMI-75
Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56Lck
Chen, Ping,Norris, Derek,Iwanowicz, Edwin J.,Spergel, Steven H.,Lin, James,Gu, Henry H.,Shen, Zhongqi,Wityak, John,Lin, Tai-An,Pang, Suhong,De Fex, Henry F.,Pitt, Sidney,Shen, Ding Ren,Doweyko, Arthur M.,Bassolino, Donna A.,Roberge, Jacques Y.,Poss, Michael A.,Chen, Bang-Chi,Schieven, Gary L.,Barrish, Joel C.
, p. 1361 - 1364 (2007/10/03)
We have identified a novel series of 1,5-imidazoquinoxalines as inhibitors of Lck with excellent potency (IC50s50s1 μM). Structure-activity studies demonstrate the requirement for the core heterocycle in addition to an optimal 2,6-disubstituted aniline group.
Imidazoquinoxaline protein tyrosine kinase inhibitors
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, (2008/06/13)
Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
Imidazoquinoxaline protein tyrosine kinase inhibitors
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, (2008/06/13)
Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
