221033-78-9

Basic information

• Product Name: 3-(3-chloro-phenyl)-4,4-dimethyl-pentanoic acid
• CAS NO: 221033-78-9
• Molecular Weight: 240.73
• Mol File: 221033-78-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(3-chloro-phenyl)-4,4-dimethyl-pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-chloro-phenyl)-4,4-dimethyl-pentanoic acid(221033-78-9)
• EPA Substance Registry System: 3-(3-chloro-phenyl)-4,4-dimethyl-pentanoic acid(221033-78-9)

Safety Data

• Hazardous Substances Data: 221033-78-9(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 1866-38-2 m-Chlorocinnamic acid 
• 594-19-4 tert.-butyl lithium 

Relevant articles and documents

On the mechanism of the addition of organolithium reagents to cinnamic acids

The regioselectivity of the addition of tert-butyllithium to cinnamic acid is subject to reaction conditions and to substituent electronic effects. Significant effects are observed in the presence of several additives including a radical trap such as α-methylstyrene. Competition experiments by addition of the organolithium reagent to mixtures of substituted cinnamic acids show that the relative rates of both conversion of the starting acids and formation of the 1,3-adducts are subject to electronic effects, whereas rates for 1,4-addition are independent of the substituents. These features are in agreement with a polar addition mechanism, but a fast SET equilibrium followed by slow radical combination would be possible as well.