22105-04-0

Usage

Uses

Used in Pharmaceutical Industry:
1-Propanone, 3-(4-bromophenyl)-1-(2-hydroxyphenyl)is used as an intermediate in the synthesis of various drugs for its ability to be incorporated into complex molecular structures, contributing to the development of new therapeutic agents.
Used in Agrochemical Industry:
1-Propanone, 3-(4-bromophenyl)-1-(2-hydroxyphenyl)is used as an intermediate in the synthesis of agrochemicals for its potential to be part of compounds that can be used in the development of pesticides or other agricultural products.
Used in Chemical Research and Development:
1-Propanone, 3-(4-bromophenyl)-1-(2-hydroxyphenyl)is used in chemical research and development for its potential applications in creating new compounds and materials, as well as for studying its chemical properties and reactivity.
It is important to handle and store 1-Propanone, 3-(4-bromophenyl)-1-(2-hydroxyphenyl)with caution, as it can be hazardous if not used properly.

Upstream product

• 65786-14-3 4-bromo-2'-hydroxylchalcone 
• 873-75-6 4-bromobenzenemethanol 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 1158952-97-6 phenyl-2-[3-(4-bromophenyl)propionyl]-4-methoxyphenyl ester 
• 20525-20-6 4'-bromoflavone 

Relevant academic research and scientific papers

Solvent-Controlled Hydrogenation of 2’-Hydroxychalcones: A Simple Solution to the Total Synthesis of Bussealins

A solvent-controlled hydrogenation of 2’-hydroxychalcones to selectively obtain different hydrogenation products is herein reported. Thus, hydrogenation of 2’-hydroxychalcones using EtOH as solvent provided the corresponding 1,3-diarylpropanes in excellent yields. On the contrary, when the hydrogenation was performed in DCM, the corresponding dihydrochalcones were isolated. Switching the reaction solvent to n-BuOH/H2O (1:1), afforded 1,3-diarylpropanols from moderate to good yields. The methodology here reported offers a straightforward, simple and cost-effective method for the preparation of a wide variety of 2’-hydroxy-1,3-diarylpropanes derivatives, and was also applied to the preparation of natural Bussealins C and D. (Figure presented.).

Iridium catalyzed alkylation of 2′-hydroxyacetophenone with alcohols under thermal or microwave conditions

2′-Hydroxyacetophenone was alkylated with a range of substituted benzyl and heteroaryl alcohols to afford the corresponding C-alkylated products in good yields under microwave irradiation. The C-alkylated products were reacted with bromoacetonitrile to afford 2-amino-3-benzyl 1,4-naphthoquinone derivatives in moderate yields.

Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors

Protein tyrosine phosphatases (PTP) are crucial elements in eukaryotic signal transduction. Several reports suggested that the LMW-PTP family has oncogenic relevance. Moreover, LMW-PTP has been recognized as a negative regulator of insulin-mediated mitotic and metabolic signaling. Thus, inhibition of the LMW-PTP can be considered an attractive approach for the design of new therapeutic agents for the treatment of type II diabetes and for new antitumoral drugs. To date very few (and weak) inhibitors of LMW-PTP have been identified. On the basis of the reported weak activity of some flavonoids on phosphatases, we discovered a lead that originated a new class of highly active LMW-PTP inhibitors; these compounds inhibit also PTP-1B and are active in cellular assays. Docking experiments and SAR highlighted the possible binding mode of these compounds to the enzyme, putting the background for the future optimization of their inhibitory activity and selectivity towards the closely related enzyme PTP-1B.