221067-99-8Relevant academic research and scientific papers
Metal-free regioselective nitration of quinoxalin-2(1H)-ones withtert-butyl nitrite
Guo, Yu,Jiang, Hong,Li, Xue-Lin,Li, Yi-Na,Liu, Yunmei,Wang, Zhen,Wu, Jin-Bo,Zeng, Yao-Fu
supporting information, p. 10554 - 10559 (2021/12/27)
A metal-free coupling of quinoxalin-2(1H)-ones withtert-butyl nitrite has been developed. Distinctly from the previous functionalization of quinoxalin-2(1H)-ones, this nitration reaction took place selectively at the C7 or C5 position of the phenyl ring, affording a series of 7-nitro and 5-nitro quinoxalin-2(1H)-ones in moderate to good yields. Preliminary mechanistic studies revealed that the reaction may involve a radical process.
Imidazoquinoxaline protein tyrosine kinase inhibitors
-
, (2008/06/13)
Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
