221077-72-1

Downstream Products

• 292835-38-2 5-{(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-[(3-phenylpropyl)amino]propyl}-2-(carboxymethoxy)benzoic acid 
• 292835-56-4 5-{(2S)-2-({(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[(4-methoxybenzyl)amino]-3-oxopropyl}-2-(carboxymethoxy)benzoic Acid 
• 292835-50-8 5-{(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-[(3-pyridinylmethyl)amino]propyl)-2-(carboxymethoxy)benzoic acid 
• 292835-53-1 5-((2S)-2-({(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-{[2-(2-pyridinyl)ethyl]amino}propyl)-2-(carboxymethoxy)benzoic Acid 
• 221076-95-5 EXAMPLE 145(Chart FF, Formula FF-2) 5-{(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-[(4-phenylbutyl)amino]propyl}-2-(carboxymethoxy)benzoic acid 
• 292835-57-5 5-{(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[(3-hydroxypropyl)amino]-3-oxopropyl}-2-(carboxymethoxy)benzoic acid 
• 292835-44-0 5-{(2S)-2-({(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[(6-hydroxyhexyl)amino]-3-oxopropyl}-2-(carboxymethoxy)benzoic Acid 
• 292835-73-5 5-((2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-{[2-hydroxy-2-(3-phenoxyphenyl)ethyl]amino}-3-oxopropyl)-2-(carboxymethoxy)benzoic Acid 
• 292835-46-2 5-[(2S)-2-({(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(phenethylamino)propyl]-2-(carboxymethoxy)benzoic Acid 
• 292835-71-3 5-{(2S)-2-({(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[(4-hydroxybutyl)amino]-3-oxopropyl}-2-(carboxymethoxy)benzoic Acid 
• 292835-52-0 5-{(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[(3-isopropoxypropyl)amino]-3-oxopropyl}-2-(carboxymethoxy)benzoic acid 
• 292835-45-1 5-((2S)-2-({(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-{[(1R)-1-(hydroxymethyl)-3-methylbutyl]amino}-3-oxopropyl)-2-(carboxymethoxy)benzoic Acid 
• 292835-42-8 5-((2S)-2-({(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-{[1-(hydroxymethyl)pentyl]amino}-3-oxopropyl)-2-(carboxymethoxy)benzoic Acid 
• 292835-64-4 5-{(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-[(3-phenylpropoxy)amino]propyl}-2-(carboxymethoxy)benzoic acid 

Relevant academic research and scientific papers

Inhibitors of protein tyrosine phosphatase

The present invention comprises small molecular weight, non-peptidic inhibitors of formula I and II of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).

Inhibitors of protein tyrosine phosphatase

The present invention comprises small molecular weight, non-peptidic inhibitors of formulae I-VII of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).