221082-63-9

Upstream product

• 68972-96-3 (Z)-1,4-dibenzyloxy-2-butene 
• 60656-87-3 benzyloxyacetoaldehyde 
• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 

Downstream Products

• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 753016-53-4 (5S,6R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methyl-5,6-dihydro-pyran-2-one 
• 753016-73-8 6-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-5,6-dihydro-2H-pyran-2-ol 
• 753016-74-9 tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane 
• 753016-54-5 tert-Butyl-[(4Z,6E)-(R)-5-ethyl-7-((2S,3S)-6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-hepta-4,6-dienyloxy]-diphenyl-silane 
• 92090-94-3 (-)-kazusamycin A 
• 642993-67-7 (2R,3R)-4-(benzyloxy)-3-[(tert-butyldimethylsilyl)oxy]-2-methylbutanal 

Relevant academic research and scientific papers

General Asymmetric Synthetic Strategy for the α-Alkylated 2,5,6-Trisubstituted Pyran of Indanomycin and Related Natural Products

A general synthetic strategy for convergent asymmetric synthesis of C1–C10 fragment of tetraene-containing natural product indanomycin was achieved starting from 2-(benzyloxy)acetaldehyde which in turn was obtained from very inexpensive material cis-1,4-butene-diol. Key steps include Evans' aldol reaction, HWE olefination, iodine-catalyzed tandem isomerization followed by C–O and C–C bond formation similar to our earlier report in constructing the trans-2,6-disubstituted dihydropyran ring and Evans' asymmetric alkylation.

First total synthesis of the antitumor compound (-)-kazusamycin A and absolute structure determination

(Equation Presented) The first total synthesis of kazusamycin A, a potent antitumor compound from an actinomycete, has been achieved, and its absolute structure was determined. Paterson's stereoselective aldol reaction was successfully applied to construct the contiguous chiral centers by using an originally designed optically active 2-acyl-1,3-propanediol derivative.