221099-71-4

Upstream product

• 221099-70-3 exo-10,10-diphenyl-10-hydroxymethyl-7,7-dimethylbicyclo[2.2.1]heptane-2-one 
• 221099-73-6 Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 100-58-3 phenylmagnesium bromide 
• 125637-45-8 (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylic acid methylester 
• 221099-74-7 (R)-Hydroxy-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 

Downstream Products

• 221099-73-6 Oxo-phenyl-acetic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 249739-64-8 2-Oxo-propionic acid (1S,2R,4R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 948854-85-1 C₃₁H₃₃NO₄ 
• 760197-69-1 3-methyl-but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 760197-67-9 hex-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 760197-72-6 2-methyl-pent-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 760197-66-8 but-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 1030379-08-8 pent-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 1030379-11-3 4-methyl-pent-2-enoic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 760197-68-0 3-phenyl-acrylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 760197-32-8 acrylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 760197-70-4 2-methyl-acrylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 1193320-11-4 4-allyloxy-3-oxo-butyric acid (1S,2R)-1-(hydroxy-diphenyl-methyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 1268671-83-5 (1S,2R,4R)-1-(hydroxydiphenylmethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl 3-oxopentanoate 

Relevant academic research and scientific papers

Novel camphor-derived chiral auxiliaries: Significant solvent and additive effects on asymmetric reduction of chiral α-keto esters

Stereoselective reduction of various α-keto esters 5a-d derived from exo-10,10-diphenyl-2,10-camphanediol 4a and exo-10,10-diphenyl-10-methoxy-2- camphanol 4b is described. High to excellent diastereomeric excess (99% de) with good chemical yields is obtained. The sense of stereoselectivity as a function of C10 modification is remarkable. Further, in the case of 5d, both diastereomers of α-hydroxyl esters can be obtained with excellent optical purity by the appropriate choice of reaction conditions. The influence of the solvents and additives on the reaction course has been investigated.

Exo-10,10-diphenyl-2,10-camphanediol as a new chiral auxiliary in asymmetric reduction

Stereoselective reduction of α-keto ester derived from exo-10,10- diphenyl-2,10-camphanediol with various hydrides proceeded with high diastereoselectivities (≥ 96% de) to afford the corresponding α-hydroxy ester with excellent yields. Change of reducing