221100-51-2

Upstream product

• 5535-49-9 2-Chloroethyl phenyl sulfide 
• 221100-47-6 (E)-5-[[2-(2-Iodo-4,5-dimethoxy-phenyl)-acetyl]-(2-phenylsulfanyl-ethyl)-amino]-pent-2-enoic acid ethyl ester 
• 221100-45-4 2-(2-iodo-4,5-dimethoxy-phenyl)-N-(3-oxo-propyl)-N-(2-phenylsulfanyl-ethyl)-acetamide 
• 221100-43-2 (3,3-diethoxy-propyl)-(2-phenylsulfanyl-ethyl)-amine 
• 221100-49-8 (E)-5-{(2-Benzenesulfinyl-ethyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

Stereoselective radical cascade approach to benzo[a]quinolizidines

The treatment of easmide 15, having an (E)-4-ethoxycarbonyl-3-butenyl group on the nitrogen atrom, with Bu3SnH-AIBN in boiling benzene, afforded a 1.2:1 mixture of two benzo[a]quinolizidine stereoisomers 16 and 17 as a result of cascade radical cyclization. A similar treatment of the (Z)-4- ethoxycarbonyl-3-butenyl congener 19 gave 16 and 17 in a ratio of 3.4:1. The high stereoselectivity (16:17=37:1) from 19 was obtained using Et3B as the initiatior at -78 °C in toluene.