221101-03-7Relevant articles and documents
Rh(II)-catalyzed asymmetric cyclopropenation of propargyl derivatives; synthesis of cyclopropene- and cis-cyclopropane-amino acids
Mueller, Paul,Imogai, Hassan
, p. 4419 - 4428 (1998)
The [Rh2{(2S)-mepy}4]-catalyzed cyclopropenation of propargylamines carrying two carboxyl or sulfonyl protecting groups with ethyl diazoacetate proceeds in high yield and with enantioselectivities in the range of 90→97% ee. Selective deprotection of the TEOC-derivative afforded ethyl 2- aminomethylcycloprop-2-ene-1-carboxylate which was converted to several analogs of γ-aminobutyric acid (GABA) containing the cyclopropene or cyclopropane ring.