22111-14-4

Usage

Chemical structure

1,4-di-2-furanyl-1,4-butanedione

Occurrence

Found in fruits such as strawberries, pineapples, and tomatoes

Aroma

Sweet, caramel-like

Usage

Used as a flavoring agent in the food and beverage industries

Synthesis

Serves as a precursor to the synthesis of other chemicals

Health relevance

Identified as a potential biomarker for oxidative stress and being investigated for potential health benefits

Allergenic effects

May cause allergic reactions in some individuals

Consumption caution

Should be consumed with caution due to potential allergenic effects

Upstream product

• 62889-08-1 1-(2-furyl)-1-(trimethylsilyloxy)ethylene 
• 98-01-1 furfural 
• 5535-48-8 PVS 

Downstream Products

• 1268165-23-6 2,5-di(furan-2-yl)-1-(4-methoxyphenyl)-1H-pyrrole 
• 1268165-20-3 1-(4-chlorobenzyl)-2,5-di(furan-2-yl)-1H-pyrrole 
• 1268165-19-0 1-(4-methoxybenzyl)-2,5-di(furan-2-yl)-1H-pyrrole 
• 1268165-22-5 2,5-di(furan-2-yl)-1-phenyl-1H-pyrrole 
• 1268165-18-9 1-benzyl-2,5-di(furan-2-yl)-1H-pyrrole 
• 1268165-24-7 1-(4-fluorophenyl)-2,5-di(furan-2-yl)-1H-pyrrole 
• 537014-76-9 benzoic acid (2R,3S,6S)-2-{2-[(2'R,3'S,6'S)-3'-hydroxy-6'-methoxy-2',3'-dihydro-6H-pyran-2'-yl]ethyl}-6-methoxy-3,6-dihydro-2H-pyran-3-yl ester 

Relevant academic research and scientific papers

Efficient synthesis of γ-keto sulfones by NHC-catalyzed intermolecular Stetter reaction

The N-heterocyclic carbene-catalyzed intermolecular Stetter reaction of aldehydes with α,β-unsaturated sulfones allows the atom-economic and selective formation of γ-keto sulfones in good yields. Key to the success of this unique transition-metal-free carbon-carbon bond-forming reaction is the right choice of the NHC precursor and base. The reaction tolerates a broad range of different aldehydes.

SYNTHESIS OF 1,4-DIKETONES BY THE COUPLING REACTION OF TRIMETHYLSILYL ENOL ETHERS WITH LEAD TETRAACETATE

Synthesis of 1,4-diketones in good yields was achieved by the coupling reaction of the trimethylsilyl enol ethers of acetophenone,thiophene or furan with lead tetraacetate in dry dichloromethane and tetrahydrofuran at -78 degC.