221112-77-2

Upstream product

• 474088-59-0 2-chloro-N-[4-chloro-2-(5-chloro-2-methoxy-benzoyl)-phenyl]-acetamide 
• 474088-58-9 (2-amino-5-chloro-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 33924-48-0 methyl 5-chloro-2-methoxybenzoate 

Relevant academic research and scientific papers

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.