22112-03-4

Basic information

• Product Name: 5-chloro-7-iodo-quinolin-8-ol
• CAS NO: 22112-03-4
• Molecular Formula: C9H5ClINO
• Molecular Weight: 305.49957
• Mol File: 22112-03-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-chloro-7-iodo-quinolin-8-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-7-iodo-quinolin-8-ol(22112-03-4)
• EPA Substance Registry System: 5-chloro-7-iodo-quinolin-8-ol(22112-03-4)

Safety Data

• Hazardous Substances Data: 22112-03-4(Hazardous Substances Data)

Upstream product

• 7647-01-0 hydrogenchloride 
• 148-24-3 8-quinolinol 
• 7732-18-5 water 
• 130-16-5 5-Chloro-8-hydroxyquinoline 
• 1371439-48-3 5-chloro-7-iodo-8-quinolinyl-β-D-glucopyranoside 
• 10173-02-1 5-chloroquinoline-8-yl acetate 
• 2598-29-0 8-acetyloxyquinoline 
• 7385-89-9 8-hydroxy-7-iodoquinoline 
• 27037-46-3 5-chloro-7-iodoquinolin-8-yl ethanoate 
• 220819-25-0 1-(5-chloro-7-iodoquinolin-8-yl)-4-<2-(2-methyl-5-nitro-1H-imidazolyl)ethyl>phthalate 
• 220819-20-5 1-(5-chloro-7-iodoquinolin-8-yl)-4-<2-(2-methyl-5-nitro-1H-imidazolyl)ethyl>butandioate 

Downstream Products

• 91240-91-4 chloro-5 iodo-7 methoxy-8 quinoline 
• 1445515-53-6 5-chloro-2-(4-nitrophenyl)furo[3,2-h]quinoline 
• 113503-81-4 5-chloro-2-p-methoxyphenylfuro<3,2-h>quinoline 
• 1445515-39-8 5-chloro-2-(4-phenoxyphenyl)furo[3,2-h]quinoline 
• 1445515-43-4 5-chloro-2-(4-phenoxyphenyl)furo[3,2-h]quinoline 
• 15731-41-6 [Cu(CQ)₂] 

Relevant articles and documents

One-pot method for preparing chloroquine chloroquine and diiodoquinoline

The method effectively solves the problems of (1) solving the problem of high isomer ratio in reaction products due to the fact that hydroxyl groups are ortho-alignment positioning groups when no guide groups are first C5 halogenated and C7 iodo, and purification difficulty is also increased. (2) The problems of poor atom economy, harsh reaction conditions, tedious aftertreatment steps and the like in first 66% steps C5 C7 C7 are effectively overcome by the method provided by the invention, and the C5-position halogenated product is 60% effectively overcome by overcoming the defects of poor atom economy, harsh reaction conditions, complicated post-treatment steps and the like in the two methods. The method has the advantages of economy of atoms, simplicity in operation, easiness in amplification and the like.

NOVEL RECYCLABLE IODINATING AGENT AND ITS APPLICATIONS

The present invention provides a novel recyclable catalysts of formula A, [Formula A should be inserted here] wherein X is selected from the group consisting of [Formula should be inserted here] The present invention also provides a novel recyclable iodinating agent of formula I, II or III and a process for the synthesis thereof. [ Formula I, II & III should be inserted here] Further, the present invention provides a process of halogenation of amines and heterocyclic compounds by employing recyclable catalyst of formula (I).

Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors

Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.