221121-28-4

Basic information

• Product Name: 2-(2-Fluoro-phenyl)-1-imidazol-1-yl-ethanone
• Synonyms: 2-(2-Fluoro-phenyl)-1-imidazol-1-yl-ethanone
• CAS NO: 221121-28-4
• Molecular Weight: 204.204
• Mol File: 221121-28-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(2-Fluoro-phenyl)-1-imidazol-1-yl-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Fluoro-phenyl)-1-imidazol-1-yl-ethanone(221121-28-4)
• EPA Substance Registry System: 2-(2-Fluoro-phenyl)-1-imidazol-1-yl-ethanone(221121-28-4)

Safety Data

• Hazardous Substances Data: 221121-28-4(Hazardous Substances Data)

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 451-82-1 (2-fluorophenyl)acetic acid 

Downstream Products

• 194943-60-7 2-(2-fluorophenyl)-1-(piperazin-1-yl)ethanone 
• 1356998-49-6 C₂₀H₂₀F₂N₂O₂ 
• 221121-59-1 6-(2-fluoro-benzyl)-5-methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 221121-52-4 6-(2-fluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 221121-35-3 ethyl 4-(2-fluorophenyl)-3-oxobutanoate 

Relevant articles and documents

Facile one-pot synthetic access to libraries of diversely substituted 3-aryl (Alkyl)-coumarins using ionic liquid (IL) or conventional base/solvent, and an IL-mediated approach to novel coumarin-bearing diaryl-ethynes

The in-situ formed carbonylimidazole derivatives of Ar(alkyl)-CH2COOH react at r.t. with substituted salicylaldehydes in [BMIM][PF6] or [BMIM][BF4] as solvent, and [PAIM][NTf2] as basic-IL, to produce libraries of 3-aryl(alkyl)coumarins. Whereas these reactions can also be performed with similar efficiency in THF by employing DBU, the IL approach offers easier work-up and recycling of the IL solvent. An IL-mediated approach to the synthesis of novel coumarin-bearing diaryl-ethynes by the Sonogshira reaction is also reported, and the potential for recycling/reuse of the IL solvent is shown.

Solvent free, N,N'-carbonyldiimidazole (CDI) mediated amidation

The method involves CDI mediated amidation under solvent-free conditions. The protocol is green, simple, and scalable and has broad structural applicability. The protocol has also been used for BOC protection of amine. The protocol has reduced the time for CDI mediated amidation from 2-4 h to 5-10 min without the use of any dry organic solvent and nitrogen atmosphere.