221121-64-8Relevant academic research and scientific papers
Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors
Fang, Zengjun,Kang, Dongwei,Zhang, Lingzi,Huang, Boshi,Liu, Huiqing,Pannecouque, Christophe,De Clercq, Erik,Zhan, Peng,Liu, Xinyong
, p. 614 - 618 (2015/10/06)
A series of novel S-DABO derivatives with the substituted 1,2,3-triazole moiety on the C-2 side chain were synthesized using the simple and efficient CuAAC reaction, and biologically evaluated as inhibitors of HIV-1. Among them, the most active HIV-1 inhi
The specific character of the reaction of derivatives of 2-thioxo-2,3-dihydropyrimidin-4(1H)-one with iodomethane and alkyl chloromethyl sulfides
Novakov,Orlinson,Nawrozkij,Mai,Artico,Rotili,Eremiychuk,Gordeeva,Brunilina,Este
body text, p. 200 - 205 (2011/08/10)
The alkylation of 5-alkyl-6-(2,6-dihalobenzyl)-2-thioxo-2,3- dihydropyrimidin-4(1H)-ones with MeI, AllSCH2Cl, and MeSCH 2Cl in the K2CO3-DMF, NaOMe-MeOH, and KOH-EtOH systems was investigated. A hypothetical mec
Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs
Yu, Mingyan,Liu, Xinyong,Li, Zhenyu,Liu, Shuai,Pannecouque, Christophe,Clercq, Erik De
experimental part, p. 7749 - 7754 (2010/03/03)
A series of novel 2-(phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones have been designed and synthesized. All of the new compounds were evaluated for their anti-HIV activities in MT-4 cells. Most of these new compounds showed mod
5-alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure - Activity relationship profile
Nawrozkij, Maxim B.,Rotili, Dante,Tarantino, Domenico,Botta, Giorgia,Eremiychuk, Alexandre S.,Musmuca, Ira,Ragno, Rino,Samuele, Alberta,Zanoli, Samantha,Armand-Ugón, Mercedes,Clotet-Codina, Imma,Novakov, Ivan A.,Orlinson, Boris S.,Maga, Giovanni,Esté, José A.,Artico, Marino,Mai, Antonello
experimental part, p. 4641 - 4652 (2009/07/04)
A series of dihydro-alkylthio-benzyl-oxopyrimidines (S-DABOs) bearing a 2-aryl-2-oxoethylsulfanyl chain at pyrimidine C2, an alkyl group at C5, and a 2,6-dichloro-, 2-chloro-6-fluoro-, and 2,6-difluoro-benzyl substitution at C6 (oxophenethyl-S-DABOs, 6-8)
Solution-phase parallel synthesis of S-DABO analogues
Togninelli, Andrea,Carmi, Caterina,Petricci, Elena,Mugnaini, Claudia,Massa, Silvio,Corelli, Federico,Botta, Maurizio
, p. 65 - 67 (2007/10/03)
A simple and straightforward methodology for the parallel, solution-phase synthesis of a new series of S-DABO derivatives 1 and 2, bearing aromatic substituents at the C2 and C6 positions, has been developed. Starting from potassium ethyl malonates 3, thi
5-alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin- 4(3H)-ones: Novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives
Mai, Antonello,Artico, Marino,Sbardella, Gianluca,Massa, Silvio,Novellino, Ettore,Greco, Giovanni,Loi, Anna Giulia,Tramontano, Enzo,Marongiu, Maria Elena,La Colla, Paolo
, p. 619 - 627 (2007/10/03)
Molecular modeling analysis of compounds belonging to the recently published series of dihydro-alkoxy-benzyl-oxopyrimidines (DABOs), such as S- DABOs and DATNOs, gave support to the design of new 2,6-disubstituted benzyl- DABO derivatives as highly potent
