22114-29-0Relevant academic research and scientific papers
Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
Cui, Xue,Li, Youbin,Ma, Jianting,Wang, Xuesong,Xu, Junyu,Zeng, Tingting
, p. 24247 - 24253 (2021/07/29)
A convenient metal-free synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones has been developed. In this procedure, various structural 2-aminopyrimidines, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represents an effective strategy towards the synthesis of unsymmetrical 2-aminopyrimidines.
Metallation Studies with Pyrimidines
Katrizky, Alan R.,Salgado, Hector J.,Chermprapai, Amornsri,Ponkshe, Narayan K.
, p. 153 - 158 (2007/10/02)
2-Alkylamino-4,6-diphenylpyrimidines are acylated only at nitrogen after treatment with lithium di-isopropylamide (LDA). 4,6-Diaryl-1-benzylpyrimidin-2(1H)-ones can be acylated and alkylated at the α-CH3 group. 1-Methyl-4,6-di-p-tolylpyrimidin-2(1H)-one f
