221146-83-4

Upstream product

• 310903-93-6 1-Acetyl-3-[1-(2-bromo-5-isopropoxy-4-methoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-4-(4-methoxy-benzyl)-piperazine-2,5-dione 
• 310903-95-8 (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-1-methyl-2,5-piperazinedione 
• 310903-94-7 (Z)-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-4-(4-methoxyphenylmethyl)-2,5-piperazinedione 
• 310903-92-5 (Z)-1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-2,5-piperazinedione 
• 310903-96-9 (Z)-3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethylene)-1-methyl-2,5-piperazinedione 
• 287117-38-8 2-bromo-5-isopropyloxy-4-methoxy-3-methylbenzaldehyde 
• 221146-78-7 3-(3-formyl-4-methoxy-5-methylphenylmethyl)-1-methyl-2,5-piperazinedione 
• 146515-59-5 3-(4-methoxy-3-methylphenylmethyl)-1-methyl-2,5-piperazinedione 
• 221146-79-8 3-(3-hydroxy-4-methoxy-5-methylphenylmethyl)-1-methyl-2,5-piperazinedione 

Downstream Products

• 310904-02-0 3-(5-benzyloxy-2-bromo-4-methoxy-3-methylphenylmethyl)-1-methyl-2,5-piperazinedione 
• 310904-06-4 2-(2-bromo-5-hydroxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-4-methyl-3-oxo-piperazine-1-carboxylic acid isopropyl ester 
• 221146-87-8 3-(2-bromo-5-hydroxy-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione 
• 310904-04-2 2-(5-benzyloxy-2-bromo-4-methoxy-3-methyl-benzyl)-6-hydroxy-4-methyl-3-oxo-piperazine-1-carboxylic acid isopropyl ester 
• 221146-84-5 3-(5-benzyloxy-2-bromo-4-methoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione 
• 221146-88-9 3-(2-bromo-5-hydroxy-4-methoxy-3-methyl-6-phenylmethyl-phenylmethyl)-4-isopropyloxycarbonyl-1-methyl-2,5-piperazinedione 

Relevant academic research and scientific papers

A practical synthesis of the ABC ring model of ecteinascidins

A practical synthesis of 1,2,3,4,5,6-hexahydro-1,5-imino-10-hydroxy-9-methoxy-3,8,11-trimethyl-3-benza zocin-4-one (3) as an ABC ring model compound of ecteinascidin 743 and safracins from 3-hydroxy-4-methoxy-5-methylbenzaldehyde (7) is described. The overall yield in 15 step is 27%.

An improved synthesis of the ABC ring model of ecteinascidins

An improved synthesis of 1,2,3,4,5,6-hexahydro-1,5-imino-9-methoxy- 3,8,11-trimethyl-4-oxo-3-benzazocine (6) as an ABC ring model compound of ecteinascidins from 3-(4-methoxy-3-methylphenylmethyl)-1-methyl-2,5- piperazinedione 3 is described.