221157-79-5Relevant academic research and scientific papers
Esterase-mediated synthesis of optically active GABA analogues containing a stereogenic all-carbon quaternary carbon atom
Felluga, Fulvia,Ghelfi, Franco,Pitacco, Giuliana,Roncaglia, Fabrizio,Valentin, Ennio,Venneri, Cesare Daniele
experimental part, p. 2183 - 2191 (2010/10/03)
Esterase from Horse Liver (HLAP) was able to hydrolyze a series of linear and cyclic β,β-dialkyl-γ-nitroesters, in spite of the well-known reluctance of hydrolytic enzymes to recognize and transform hindered substrates, such as those possessing a stereoge
A Novel and Highly Stereoselective Approach to Aza-Spirocycles. A Short Total Synthesis of 2-epi-(±)-Perhydrohistrionicotoxin and an Unprecedented Decarboxylation of 2-Pyrones
McLaughlin, Michael J.,Hsung, Richard P.,Cole, Kevin P.,Hahn, Juliet M.,Wang, Jiashi
, p. 2017 - 2020 (2007/10/03)
(Matrix Presented) A novel and highly stereoselective synthesis of aza-spirocycles is described. An application of this methodology is illustrated as a short and concise total synthesis of 2-epi-(±)-perhydrohistrionicotoxin with high diastereomeric contro
Identification of novel ligands for the Gabapentin binding site on the α2δ subunit of a calcium channel and their evaluation as anticonvulsant agents
Bryans, Justin S.,Davies, Natasha,Gee, Nicolas S.,Dissanayake, Visaka U. K.,Ratcliffe, Giles S.,Horwell, David C.,Kneen, Clare O.,Morrell, Andrew I.,Oles, Ryszard J.,O'Toole, John C.,Perkins, Gemma M.,Singh, Lakhbir,Suman-Chauhan, Nirmala,O'Neill, Jacqueline A.
, p. 1838 - 1845 (2007/10/03)
As part of a program to investigate the structure-activity relationships of Gabapentin (Neurontin), a number of alkylated analogues were synthesized and evaluated in vitro for binding to the Gabapentin binding site located on the α2δ subunit of
