22117-22-2Relevant academic research and scientific papers
meso-Phbox-Pd(II) catalyzed tandem carbonylative cyclization of 1-ethynyl-1-propargyl acetate
Kato, Keisuke,Teraguchi, Ryuhei,Motodate, Satoshi,Uchida, Akira,Mochida, Tomoyuki,Peganova, Tat'yana A.,Vologdin, Nikolai V.,Akita, Hiroyuki
supporting information; experimental part, p. 3687 - 3689 (2009/02/05)
Palladium(II) catalyzed carbonylation of 1-ethynyl-1-propargyl acetate 1 is described; in the absence of the bisoxazoline (box) ligand, the second triple bond did not react, affording cyclic orthoesters 3 and 4. The use of meso-Phbox-Pd(II) strikingly changed the course of the reaction, yielding bicyclic lactone 2 by tandem carbonylative cyclization as a result of insertion of the second triple bond. The Royal Society of Chemistry.
