221178-84-3

Upstream product

• 19310-87-3 4-(2,2-dicyanovinyl)phenyl acetate 
• 221178-82-1 4-(2,6-diamino-3,5-dicyano-4H-thiopyran-4-yl)phenyl acetate 
• 7357-70-2 Cyanothioacetamide 

Relevant academic research and scientific papers

Synthesis and Recyclization of 4-Aryl-2,6-diamino-3,5-dicyano-4H-thiopyrans

Reaction of arylmethylenemalononitriles with cyanothioacetamide or of arylmethylenecyanothioacetamides with malononitrile affords 4-aryl-2,6-diamino-3,5-dicyano-4H-thiopyrans which were further recyclized into 6-amino-4-aryl-3,5-dicyanopyridine-2(1H)-thiones. On the basis of the latter compounds were synthesized substituted 2-alkylthiopyridines and thieno[2,3-b]pyridines. 4-Hydroxybenzalcyanothioacetamide reacts with α-bromoketones by Hantzsch with the formation of thiazolylsubstituted acrylonitriles acylated with acetic anhydride at the OH group.