221179-29-9Relevant academic research and scientific papers
First efficient two-step/one-pot zirconium (IV)isopropoxide-mediated reductive amination of carbonyl compounds
Pieri, Cyril,Brunel, Jean Michel
, p. 448 - 456 (2015/06/22)
An efficient method for the synthesis of various primary and secondary amines through a zirconium(IV) isopropoxide-mediated reductive amination reaction of aldehydes and ketones is reported. A series of different aldehydes, ketones and amines were used leading to the expected amino products in moderate to excellent yields. The mechanistic rationale of this reaction has been postulated through the formation of a transient imine species and a diastereoselective version using (R)-phenylethylamine as chiral inducer led to the expected products in moderate to excellent yields and with diastereoselectivities up to 100%.
Stereo- and regioselectivity in asymmetric synthesis of α-amino substituted benzocyclic compounds
Gutman, Arie L.,Etinger, Marina,Nisnevich, Gennady,Polyak, Felix
, p. 4369 - 4379 (2007/10/03)
The enantiomerically pure chiral benzocyclic amines 6-8 were obtained by asymmetric transamination of the corresponding prochiral ketones 9a-c. The method involves: (a) formation of chiral imines 10a-c from the prochiral ketones 9a-c and the inexpensive c
