221187-05-9Relevant academic research and scientific papers
HISTONE DEACETYLASE INHIBITOR AND PROCESS FOR PRODUCING THE SAME
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, (2008/06/13)
HDAC inhibitors represented by formula (1) show strong inhibitory activity against various subtypes of HDACs. The compounds of the present invention find utility as pharmaceutical agents for treating or preventing diseases associated with HDAC 1, 4, and 6
Histone deacetylase inhibitors and process for producing the same
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Page/Page column 11-12, (2008/06/13)
Compounds represented by formula (1) have strong inhibitory activity that is selective towards HDAC1 and HDAC4. Therefore, the compounds of the present invention are useful as pharmaceutical agents for treating or preventing diseases caused by HDAC1 and HDAC4.
Cyclic Tetrapeptides Bearing a Sulfhydryl Group Potently Inhibit Histone Deacetylases
Nishino, Norikazu,Jose, Binoy,Okamura, Shinji,Ebisusaki, Shutoku,Kato, Tamaki,Sumida, Yuko,Yoshida, Minoru
, p. 5079 - 5082 (2007/10/03)
(Equation presented) New inhibitors of histone deacetylase (HDAC) containing a sulfhydryl group were designed on the basis of the corresponding hydroxamic acid (CHAP31) and FK228. Their disulfide dimers and hybrids exhibited potent HDAC inhibitory activity in vivo with potential as anticancer prodrugs.
