221197-99-5Relevant academic research and scientific papers
Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl- 2-phenyl-[1,3]dioxolan-2-ylmethyl)lactam methiodides
Malmusi, Luca,Franchini, Silvia,Mucci, Adele,Angeli, Piero,Gulini, Ugo,Marucci, Gabriella,Brasili, Livio
, p. 499 - 509 (2007/10/03)
A series of 1,3-dioxolane-based ligands, having a lactam function were synthesized and tested as potential muscarinic antagonists. The compounds display moderate affinity for the three receptor subtypes M1-M3, with significant selectivity for the M1-M3 over the M2 subtype.
